And some werewolves are considered separate species from humanity, at least in the Old World of Darkness novels.

Which is interesting, because despite all of this, in that universe, werewolves breed with humans and wolves, and it is preferable to do so, because werewolf/werewolf mating was often bad news, as the offspring would be sterile.

So it's not really a species barrier. On top of that, or werewolves generally involve themselves in bestiality all the time.